Microglia in Glioblastoma Invasion
Led by Marc Symons, PhD at the Center for Oncology and Cell Biology at The Feinstein Institute for Medical Research

Malignant gliomas have a main tumor, but also invade neighboring brain tissue with individual cells. These invading cells are highly resistant to radiation and chemotherapy, leading to recurrence after treatment. Microglia cells are released by the central nervous system and interact with cancer cells. Their removal has been shown to inhibit glioblastoma invasiveness.

Currently, there are no anti-invasive therapies available. At the same time, studies on microglia cells and their effect on tumors are lacking. This research aims to study the cell interaction and to identify novel targets for therapeutic intervention in this devastating disease.

 
Click here for a full list of research grants funded by Voices Against Brain Cancer.