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F. Avraham Dilmanian, PhD

Current Position

Scientist, Medical Department, Brookhaven National Laborator
Associate Professpr, Radiology Oncology Department, SUNY Stony Brook

BS, Technion, Israel Institute of Technology, Haifa, Israel
MS, Technion, Israel Institute of Technology, Haifa, Israel
PhD, Massachusetts Institute of Technology, Cambridge, MA
Postdoc Res. A, Washington University, St. Louis, MO
PhD in Biophysics, University of Chicago

Personal Statement
The goal of the proposed research is to investigate the efficacy of the new radiosurgery method “interlaced carbon microbeams” to treat a highly malignant brain tumor model in the rabbit brain and spontaneous glioma brain tumors in pet dogs. The rabbit studies will be compared with those using broad carbon beams administered in the same 4-direction geometry. The project will also measure the dose response of the normal rabbit brain to unidirectional carbon microbeams and broad beams. I have been one of the initiators of the method “microbeam radiation therapy” using arrays of very thin, 25-90 µm, synchrotron-generated x rays. The work was carried out in the early 1990s together with Drs. Daniel Slatkin, the late Per Spanne, and Jean Laissue at the National Synchrotron Light Source (NSLS), Brookhaven National laboratory (BNL). In the early 2000s I came to be the lead author of several peer-reviewed publications on the method. Later in the 2000s I initiated the use of much thicker microbeams, up to 0.68 mm, and the interlaced x-ray microbeams method that used those thick beams. Those works of ours were presented in three peer-reviewed publications in which I was the lead author. Finally, I have been the initiator of the technique interlaced carbon microbeams, using beams from the NASA Space Radiation Laboratory (NSRL) at BNL. Our preliminary results on the subject, presented in this proposal, include the tolerance of the rat brain to high dose iron microbeams, and the ablation of a 6.5-mm target in the rabbit brain with interlaced carbon microbeams producing little or no damage to the surrounding tissues. I am also a co-author and a lead author of two Monte Carlo simulation papers calculating the dose distributions from arrays of thin x-ray microbeams in phantoms. Finally, I currently have a grant from the New York State Spinal Cord Research Program to evaluate the effectiveness of arrays of x-ray microbeams in assisting the recovery of rats with contusion spinal cord injuries. The method has already produced encouraging results.

Positions and Employment

1986. Chief Physicist, Nuclear Medicine Div., Elscint Ltd., Haifa, Israel

1986-1986 Visiting Scientist, Dept. of Nuclear Physics, The Weizmann Institute of Science, Rehovot, Israel

1987-1989 Senior Research Associate, Medical Department, Brookhaven National Laboratory (BNL)

1987-2000 Assistant Professor, Department of Radiology, SUNY SB (unpaid)

1989-1992 Associate Scientist, Medical Department, BNL

1992-present Scientist, Medical Department, BNL

2000-present Associate Professor of Radiology and Biomedical Engineering, SUNY SB (unpaid)

2007-present Associate Professor of Research (paid part-time), Department of Radiation Oncology, SUNY SB



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